Drugs metabolized by CYP3A4 are called CYP3A4 substrates. HIV PIs can be CYP inducers, inhibitors, and substrates. Sulphonylureas Carbamezapine Rifampin Alcohol Phenytoin Griseofulvin Phenobarbital. A. rbituates . S. t Johns wort . The main concept my professor is testing here is inducer/inhibitors of cyp and whether we should use ketoconazole, a drug that inhibits the same CYP enzyme as cimetidine. //-->, sitemap A basic knowledge of cytochrome p450 enzymes helps to understand many drug interactions. Commonly tested P450 inhibitors include cimetidine, ketoconazole, erythromycin, ciprofloxacin, indinavir, acute alcohol use, isoniazid, grapefruit juice, quinidine and sulfonamides. As a result, the dose of such drugs (which are metabolized by microsomal enzymes) should be increased when administered along with enzyme inducers. Start studying G <3 PACMAN (BIG CYP INHIBITORS). Enzyme inhibitors are drugs which decrease the metabolism of drugs by inhibiting microsomal enzymes. Don't forget to visit it for more mnemonics and useful tips on creating one. Hello everyone. Pharmacology Mnemonics The best medication mnemonics for medical student finals, OSCEs and MRCP ACE inhibitor side effects (CAPTOPRIL) Cough Angioneurotic oedema Proteinuria Taste disturbance/ Teratogenic in 1st trimester Other (fatigue, headache) Potassium increased Renal impairment Itch Low BP (1st dose) Beneficial effects of inhibition of prostaglandin synthesis i.e. P450 inhibitors are drugs that decrease the activity of the enzyme causing drugs that are also metabolized by the P450 system to be metabolized at a decreased rate. Clin Pharmacol Ther. Inducers of CYP3A4 include phenobarbital, phenytoin, rifampicin, St. John’s Wort and glucocorticoids. Keep in mind that many drugs are metabolized by more than one CYP450 enzyme, and CYP3A4 may represent only one pathway. Dec 12, 2016 - P450 Enzyme Mnemonics, Inhibitors & Inducers Drugs causing CYP 450 inhibition are important in pharmacology because of their drug interactions. Patients who have sulfa (sulfonamide) allergies will have a wide range of allergies to the following sulfa drugs Wikipedia - Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. YouTube google_alternate_ad_url = "http://www.rxpgonline.com/google_adsense_script.htm"; You will most likely have a question about drug interactions and you will be expected to know the basics of major drug interactions as well as how the drugs affect each other.Say that you have 34 year male who on Clopidogrel (Plavix®). TL;DR and timeline at the bottom. google_ad_width = 728; SCRAP GP. Tags: USMLE MBBS Learn vocabulary, terms, and more with flashcards, games, and other study tools. 2011;90(5):666-673. doi: 10.1038/clpt.2011.164. - Mnemonics Home | Add a ... Top Rated: Mnemonics: Pharmacology: CYP3A4 enzyme inhibitors: CYP3A4 enzyme inhibitors: Posted by shruti1989 on 15-Dec-2011: 16848 people have seen this mnemonic. Learn Cytochrome P450 enzyme inducers and inhibitors using these mnemonics. INHIBITORS: INDUCERS: SUBSTRATES: CYP1A2: CYP3A4: cimetidine ciproflxacin enoxacin erythromycin ***fluvoxamine grepafloxacin isoniazid mexiletine norfloxacin tacrine zileuton: barbiturates carbamazepine charcoal-broiled foods lansoprazole omeprazole phenytoin rifampin smoking: amitriptyline caffeine clomipramine clozapine google_ad_client = "pub-3203824303187431"; Moderate inhibitor being one that causes at least a 2-fold increase in the plasma AUC values, or 50-80% decrease in … Medical Solutions Private Limited, Chrome Web Store Cytochrome P450 inhibitors . google_ad_type = "text_image"; Please enable JavaScript to use all features in RxPG. 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